The Food and Drug Administration (FDA) approves prescription drugs such as Injectafer to treat certain conditions. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. It is given into a vein for a period of time. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. Iron sucrose can also be mixed in a. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Side effects like nausea and low blood pressure are common with most iron infusions. (A class of medications describes a group of drugs that work in the same way.). stream Injectafer comes as a liquid solution inside vials. (A medication class is a group of medications that work in a similar way.). But you kidneys need iron in order to make EPO. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Before using, check this product visually for particles or discoloration. If your symptoms or health problems do not get better or if they become worse, call your doctor. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If that happens, and your doctor thinks Injectafer is a good treatment option for you, you can receive another treatment course of the drug. Serious side effects from Injectafer arent common, but they can occur. And this person had gotten their first dose of the drug without having an allergic reaction. Do not share your drugs with others and do not take anyone else's drugs. Venofer may reduce the absorption of iron preparations taken by mouth. With IV infusion, the drug is given as a slow drip into your vein over a period of time. (IV iron is absorbed by the body more rapidly than oral iron.) You may also need to monitor your blood pressure at home. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. Since someallergic reactionscan belife-threatening, its essential to discuss any adverse events previously experienced with the prescribingphysician. They can recommend appropriate treatment options. pain or burning at the injection site. There have also been reports of serious allergic reactions to Venofer. It depends. The body cannot metabolize such a high dose fast enough, so it ends up affecting a part of the body it wasnt intended to, such as the stomach. People who weigh 110 pounds (about 50 kilograms) or more will receive two separate Injectafer doses of 750 milligrams each. It's a more immediate treatment than supplements or dietary changes. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Venofer is used to treat iron deficiency anemia in people with kidney disease. In the first group, some people continued taking iron by mouth, while other people took Injectafer. For more information about Injectafers approved uses, see the section Injectafer uses below. And this would give you a total cumulative Injectafer dose of 1,440 mg. Injectafer should be given in two doses. However, since peoples bodies react so differently to drugs, they often have to change their stance on certaindrugs. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. In this study, researchers compared Feraheme treatment with that of ferric carboxymaltose (the active drug in Injectafer). Iron sucrose can make it harder for your body to absorb iron medications you take by mouth. In clinical trials, serious allergic reactions occurred in 0.1% to 1.5% of people taking Injectafer. These lists contain examples of serious side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). In the US - Call your doctor for medical advice about side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Spacing your Injectafer doses out at least 7 days helps to reduce your risk of side effects. With IDA, you have low hemoglobin levels. WebMD does not provide medical advice, diagnosis or treatment. This is a sudden response affecting the entire body, which sometimes happens to people who are allergic to peanuts or beestings. If administering via IV infusion, up to 750 mg of Injectafer should be diluted in no more than 250 mL of sterile 0.9% sodium chloride solution (NaCl). Mild side effects of Injectafer can include:*. Drug interactions may change how your medications work or increase your risk for serious side effects. Use of the term female in this article refers to sex assigned at birth. Use Venofer as ordered by your doctor. Nausea. In some cases, they may even recommend that you use a drug other than Injectafer to treat your anemia. After the infusion, you can drive yourself home and return to your usual activities. Copyright 1996-2023 Cerner Multum, Inc. But you likely wont feel the drug working inside of you. Call your doctor right away if youre having a severe allergic reaction to Injectafer, even if youve had doses of the drug in the past without any problems. Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Now I've just got mild nausea and have felt faint/dizzy a few times which is rare for me. It is very important that your doctor check you closely while you are receiving this medicine. Without enough hemoglobin, the right amount of oxygen may not reach certain parts of your body. They can recommend if this is safe for you to do. This treatment course is split into two doses of the drug, which are given at least 7 days apart. But so far I feel better than before the infusion. For example, some people with anemia have extreme fatigue (lack of energy), which can make it hard for them to exercise. Cancer patients who have anemia and are taking an ESA. Although a single administration of FCM frequently causes transient hypophosphatemia, a 2016 study showed that repeated treatment with FCM is associated with a high risk of developing severe and prolonged hypophosphatemia and should therefore be monitored. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). If you would like to report to the FDA a side effect youve had with Injectafer, you can do so through MedWatch. SIDE EFFECTS: In adult patients, the most common side effects (2%) include diarrhea, upset stomach, throwing up, headache, dizziness, hypotension, pruritus (itching), pain in extremity, arthralgia (joint pain), back pain, muscle cramp, injection site reactions, chest pain and peripheral edema (swelling). I had Venofer infusions, 2 rounds now in the span of three years. Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft). Injectafer contains the active drug ferric carboxymaltose. How is Venofer (iron sucrose) given? Call your doctor for instructions if you miss an appointment for your Venofer injection. It belongs to a class of medications called iron replacement products. What should I know regarding pregnancy, nursing and administering Venofer Vial to children or the elderly. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking Injectafer. Injectafer and Venofer can cause very similar side effects, but some different ones as well. (Hemoglobin is a protein thats found inside your red blood cells.). You would receive 15 mg of Injectafer per kilogram of body weight for each of your two doses. As described just above in the Allergic reaction section, some people may have an allergic reaction after getting a dose of Injectafer. Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. %PDF-1.3 But for other people, their IDA returns after treatment with Injectafer. These pregnancy-related problems include preterm delivery and low birth weight of your infant. Last updated August 20, 2020. Together, they can recommend ways to help you manage a body weight thats healthy for you. Phosphorus is an electrolyte that your body needs in order to make energy. experience severe side effects, please seek medical attention right away and notify the ordering physician. Brand-name medications usually cost more than generics. If you have any questions about Venofer, please talk with your doctor, nurse, pharmacist, or other health care provider. Boxed warnings alert doctors and patients about drug effects that may be dangerous. How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. Feraheme also comes as a liquid thats given by IV infusion. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. I was surprised too but the Dr said it definitely sounds like a reaction. Infusion times range from less than 20 minutes to up to 4 hours. If you have questions about the best diet for you during Injectafer treatment, talk with your doctor. You should not receive Venofer if you have known allergies to iron sucrose. Joint pain. Severeside effectscan lead to injury or death -drowsinesscan cause a car accident or injury when operating heavymachinery. You may need extra iron because of blood loss during kidney dialysis. Injectafer isnt a medication that youll take regularly on a schedule. Effectiveness of Injectafer compared with iron thats taken by mouth. Together, you and your doctor can develop a treatment plan thats best for you. Depending on your doctors instructions and
Brand-name medications usually cost more than generics. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. The infusion will take between 15-30 minutes if it is given in. And this can affect how well those parts of your body are able to work. endobj Call your doctor for medical advice about side effects. The potential side effects of Daxxify are nearly identical to that of Botox bruising, headaches, and droopy eyelids with one big difference: They could last longer. For instance, there are some experts who believe there are long-lastingside effectsfromCOVIDthat were not aware of just yet. Not all possible drug interactions are listed here. This is not a complete list of side effects and others may occur. Venofer injection contains iron sucrose, a form of the mineral iron. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. Taking a higher dose than needed can often lead to adverse effects. These nutrients include iron, vitamin B12, and folate. Generic name: iron sucrose (injection) [EYE-urn-SOO-krose] Properly discard this product when it is expired or no longer needed. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Phosphorus also helps your nerves function properly. Injectafer contains the active drug ferric carboxymaltose. Here we look at how Injectafer and Feraheme are alike and different. Medically reviewed by Sanjai Sinha, MD. (One treatment course includes two doses of the drug.) If you notice any changes to your normal blood pressure, call your doctor right away. The following information is provided for clinicians and other healthcare professionals. 2023 Medicine.com All rights reserved. Orofer S 50 Injection 1 Injection in 1 Packet 147. Venofer pregnancy and breastfeeding warnings. As a result, you may not make as much EPO as usual. ByDr. Venofer is indicated to treat iron deficiency anemia (IDA) in adult and pediatric patients (2 years and older) with chronic kidney disease (CKD). Dilute Venofer in a maximum of 250 mL of 0.9% NaCl. . Data on file, American Regent, Inc. 1. Injectafer is available only as a brand-name medication. Venofer may cause serious side effects including: problems with your dialysis vein access point, chest pain, severe headache, blurred vision, pounding in your neck or ears, lightheadedness, pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, and fever Get medical help right away, if you have any of the symptoms listed above. If you miss an appointment for your Injectafer dose, youll need to call your doctors office. In clinical studies, people who took Injectafer had their hemoglobin level improve as early as 35 days after receiving treatment. Venofer is for use in adults and children at least 2 years old. You may report side effects to the FDA at 1-800-332-1088. It can be given as a slow injection over 2 to 5 minutes or as an infusion. * This is a partial list of mild side effects from Injectafer. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. Dr. Colby holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford Universitys Graduate School of Business, and a degree in Genetics with Honors from the University of Michigan. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. 5 0 obj Notify your healthcare provider of any irritation at the injection site. Additional studies are ongoing to see if Injectafer is a safe and effective treatment option for these conditions. Learn how to store and discard medical supplies safely. Since side effects are similar between 150 mg and 300 mg, a larger dose may increase severity or frequency of side effects. People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. This medication is given by injection into a vein as directed by your doctor. It is important to get each dose of this medication as scheduled. Both Injectafer and Venofer belong to a class of medications called iron replacement products. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Keep in mind that the risk of certain pregnancy-related problems can be increased if iron deficiency anemia (IDA) is left untreated. Your doctor will recommend whether you should stop taking your multivitamin or any other supplements. Iron infusions are given directly into a vein. For more information and to find out if youre eligible for support, call 877-4-IV-IRON (877-448-4766) or visit the program website. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. 1xo`[kg'#KS#.#`uv:PM1+Ob`>y/8:6Ghl:y9B+-,9m[ (Hemoglobin is a protein thats found in your red blood cells.). If you need to store Venofer at home, talk with your doctor, nurse, or pharmacist about how to store it. But for other people, doing so could lead to having too much iron in their body. Venofer® (iron sucrose injection, USP) is available by prescription only. VenAccess is a trademark of Vifor (International) Inc. Switzerland. With anemia, you have a low level of red blood cells (RBCs) in your body. Theyll likely have you stop taking the pills while youre using Injectafer. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Back pain. Iron-refractory iron deficiency anemia (IRIDA) is a genetic form of anemia. (See also Notes section.). You may report side effects to FDA at 1-800-FDA-1088. So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. Any long-term side effects/dangers from iron infusions? Its not known if Injectafer is safe to use during pregnancy. Also tell them about any vitamins, herbs, and supplements you use. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. For more information on the possible side effects of Injectafer, talk with your doctor or pharmacist. (Hemoglobin is a protein thats found in red blood cells.). Some people are simply allergic to an active ingredient in the medication, so the body responds undesirably. But its only approved for use in people with CKD who may or may not need dialysis. If you have questions about side effects, call your doctor. However, there has been a report of delayed allergic reaction in someone receiving a second dose of Injectafer. However, consuming large amounts of alcohol can actually cause anemia in some people. People with IDA have low blood levels of hemoglobin. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Venofer (iron sucrose) is given as an injection into the veins (intravenously or IV) by a trained healthcare provider. Serious side effects, which are explained in more detail below in Side effect details, include: You may wonder how often certain side effects occur with this drug. With a delayed reaction, your body reacts to a drug that youve been exposed to in the past without having a reaction. But in some people, Injectafer can cause symptoms of hypophosphatemia to occur. fever. Injectafer is approved to treat iron deficiency anemia (IDA) in certain adults with the condition. For some people, after receiving one treatment course (two doses) of Injectafer, their IDA is resolved. You should not be treated with this medicine if you have ever had an allergic reaction to an iron injection. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. Last updated on Feb 20, 2023. There may be risks to the mother and fetus associated with untreated IDA in pregnancy. Many people believe they are suffering fromside effectsand may actually be suffering from anothermedical condition, such as havingdifficulty breathingorshortness of breath, which could be a heartattack. Call your doctor for medical advice about side effects. Back pain. Serious side effects should be reported to a physician and/or PharmD for medical advice. What are the side effects of Venofer? I used to get a different type but my . A variety of tests can diagnose iron deficiency anemia. After 5 weeks of treatment: This study didnt determine if either drug was better than the other. You will need frequent medical tests to help your doctor determine how long to treat you with Venofer. But call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. This is not a complete list of side effects and others may occur. Learn more about these, as well as the symptoms, diagnosis, and treatments. This product may contain inactive ingredients, which can cause allergic reactions or other problems. But they wont receive a total cumulative dose of more than 1,500 mg of Injectafer. You may also report side effects at https://www.fda.gov/medwatch. In clinical trials,. However, to be safe, tell your doctor or pharmacist about all prescription, over-the-counter, and other drugs you take before taking Injectafer. You may report side effects to FDA at 1-800-FDA-1088. But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. Injectafer is indicated to treat iron deficiency anemia (IDA) in adults who meet one of the following criteria: Injectafer is administered intravenously, either by intravenous (IV) infusion or as an undiluted, slow IV push. Venofer also comes as a liquid thats given by either IV infusion or a slow IV injection. This could happen because Injectafer helps increase their hemoglobin levels, but it doesnt address the underlying cause of their anemia. Maximum concentrations of Injectafer are achieved within 15 minutes to 1.21 hours following administration. You may report side effects to the FDA at 1-800-332-1088. As with all medications, the cost of Injectafer can vary. Hypophosphatemia has been reported in people using Injectafer after the drug was released onto the market. However, side effects at the 150 mg dose may indicate that you might not . This may lead to the person needing a higher dose compared to someone who is muchsmaller. Youll receive doses of Injectafer from a healthcare professional at a medical facility. In the study, peoples hemoglobin level was measured to check for improvement in their anemia. In stock alternatives of Venofer (based on Iron Sucrose ) Orofer S 200 Injection 1 Injection in 1 Packet 540 569 5% off. A delayed reaction can occur in two different ways: It can happen hours or days after you receive a drug, or it can happen after a second (or later) dose of a drug. Call your doctor right away if you have serious side effects. This can be very helpful in . It will take about three weeks to feel the effects but your fatigue will disappear and you will feel like a new person. endobj Its given by either intravenous (IV) infusion or slow IV injection. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Heres some detail on certain side effects this drug may cause. generalized weakness. signs of inflammation in the lining of your stomach --pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. wAd**CgI%"nn{Oa[q{r5 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Selected from data included with permission and copyrighted by First Databank, Inc. Side effects from HRT depend on a number of factors: xmq92\Kz!yIP}2~(?c/JUCK2~o_N=>K$o/_7'Z+nRkKM^y{u|ZFh$v}]O~vfo=.GowGFodVj-[-~x]Kg~9H'%h={OX/#S|Mc~|]_2nv`wwotn/+$G[{hGrP}sbZG-RGf#l~~l|Qnccml_iPy]G\17c,yPF[28z&I'+B(?rrvi,G?}/;'?;pm>?.i42ONmk~ai_u0z9o_? Patients with iron-deficiency anemia who are having high blood loss surgery (> 500 ml) within the next 2 months and need to replace iron quickly. Procedure Details Blood tests may be needed to check for unwanted effects. Severeside effectsmay end up causing a lot of disruption in a persons life. And theyll recommend how soon after starting the drug you need to have this level checked. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. No, you dont need to follow a specific diet plan while youre using Injectafer unless your doctor recommends otherwise. Call your doctor for medical advice about side effects. Many patients with kidney disease cannot get enough iron from food and require injections. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. <> On day three I had a headache and felt heavy/exhausted, which lasted a few days. A healthcare provider will give you this injection. Your doctor will go over your
They can give you tips on how to deal with any side effects that may be bothersome. * Sex and gender exist on spectrums. This is because alcohol reduces your bodys absorption of certain nutrients that are necessary to make red blood cells. You will be watched closely by your doctor for 30 minutes after each dose. Its not currently available in generic form. The researchers found that compared with their hemoglobin level before the study: But the actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. HRT, like other medications, does have some side effects and these are thought to be quite common. It belongs to a class of medications known as iron replacement products. With IV infusion, the drug is given as a slow drip into your vein over a period of time. * Feraheme has a boxed warning for this side effect. Orofer S 100 Injection 1 Injection in 1 Packet 286 301 5% off. weakness. Instead, youll start by receiving just one treatment course of Injectafer. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics(ACMG), an Associate of the American College of Preventive Medicine(ACPM), and a member of the National Society of Genetic Counselors(NSGC). This survey is being conducted by the WebMD marketing sciences department. In clinical studies, Injectafer was effective in treating IDA in adults who either didnt improve with or had side effects from taking iron by mouth. These tests will help make sure Injectafer is working to treat your iron deficiency anemia (IDA). The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Available for Android and iOS devices. fluid retention, especially in your arms, legs, or feet, people who took Feraheme had their hemoglobin level increase, on average, by 1.38 grams per deciliter (g/dL), people who took ferric carboxymaltose had their hemoglobin level increase, on average, by 1.63 g/dL, having strange cravings to eat items that arent food, such as ice, people who took Injectafer had their hemoglobin level increase, on average, by 1.6 grams per deciliter (g/dL), people who kept taking iron by mouth had their hemoglobin level increase, on average, by 0.8 g/dL, people who took Injectafer had their hemoglobin level increase, on average, by 2.9 g/dL, people who took the other intravenous iron product had their hemoglobin level increase, on average, by 2.2 g/dL, people who took Injectafer had their hemoglobin level increase by an average of 1.1 g/dL, people who took Venofer had their hemoglobin level increase by an average of 0.9 g/dL, cannot tolerate or have shown a poor response to oral iron, or, have been diagnosed with chronic kidney disease (CKD) that is non-dialysis dependent. Innovators Monograph Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. I can't take oral supplements because they cause horrible debilitating Constipation. No, you wont need to take iron pills while youre using Injectafer. If you do breastfeed while youre taking Injectafer, the drugs manufacturer recommends that you monitor your child for side effects of the drug. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. For additional information, contact your healthcare provider. Heart failure: Could a low sodium diet sometimes do more harm than good? They have been a god send. This is not a complete list of possible side effects. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. This includes your doctors, nurses, pharmacists, and dentists. signs of inflammation in the lining of your stomach - pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. In the studies, peoples hemoglobin level was measured to check for improvement in their anemia. Dr. Colby is alsothe Founder of Sequencing.com and the authorofOutsmart Your Genes. Its responsible for carrying oxygen throughout your body. In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. Check with your pharmacist if you have questions about the best way to throw out drugs. endobj They can tell you about other medications that may work well for you. Typical Injectafer doses for iron deficiency anemia (IDA) depends on your body weight. This gives a total cumulative dose of 1,500 mg of Injectafer. Its not known if Injectafer is safe to take during pregnancy. Very bad and sometimes deadly allergic side effects have rarely happened. Venofer Side Effects. Keep in mind that there may be additional costs related to getting your doses of the drug at a medical facility. This is only a brief summary of general information about this medicine. After receiving IV iron therapy, you will be monitored for 30 minutes to make sure you do not have an allergic reaction or a drop in blood pressure. After getting each dose of Injectafer, your healthcare professional will monitor you for at least 30 minutes. On the other hand, some people may have a poor appetite that goes away when their anemia is treated. Youll receive doses of either drug by a healthcare professional at a medical facility. This is why family members often have the same issues with drugs as others in theirfamily. Version: 7.01. What is Venofer? Keep all medications away from children and pets. Possibleside effectsareweight gainand suicidal thoughts. If youre not sure if youll need to get prior authorization for Injectafer, contact your insurance company. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. You must check to make sure that it is safe for you to take Venofer with all of your drugs and health problems. A boxed warning is the most serious warning the Food and Drug Administration (FDA) can issue about a drug. If you have any of these health problems: Too much iron in your body or anemia from a cause other than low iron.
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